Multiplex CRISPR-Editing of Wood for Sustainable Biomaterials Production演講公告
森林環資系演講公告
演講題目：Multiplex CRISPR-Editing of Wood for Sustainable Biomaterials Production
主講人：Jack P. Wang, Ph.D., Professor & Director of Forest Biotechnology Group, Department of Forestry & Environmental Resources, North Carolina State University, USA
演講摘要：
Wood is the most abundant carbon biomass on earth and the major source of sustainable green fibers and bioproducts. Globally, 315 gigatons of carbon are stored as wood, representing 57% of the biogenic carbon sink. Despite the importance of wood products, their production has remained largely limited to undomesticated forest trees with often sub-optimal wood properties that hamper production efficiency. Here, we show that strategic multiplex CRISPR-based genome editing of monolignol biosynthesis genes improves wood properties beyond natural variations or the editing of single genes. By assessing every possible combination of multigenic-editing strategies for 21 lignin biosynthesis genes, we deduced unique genome-editing strategies targeting the concurrent alteration of up to 6 genes. CRISPR-editing increased the wood carbohydrate-to-lignin ratio up to 228% of wildtype, leading to more efficient bioprocessing. The edited wood alleviates a major fiber-production bottleneck and could bring unprecedented operational efficiencies, bioeconomic opportunities, and environmental benefits.
日期：2024年5月29日(星期三)
時間：10:20-12:10 AM
地點：臺大森林系館 林一教室
演講題目：Multiplex CRISPR-Editing of Wood for Sustainable Biomaterials Production
主講人：Jack P. Wang, Ph.D., Professor & Director of Forest Biotechnology Group, Department of Forestry & Environmental Resources, North Carolina State University, USA
演講摘要：
Wood is the most abundant carbon biomass on earth and the major source of sustainable green fibers and bioproducts. Globally, 315 gigatons of carbon are stored as wood, representing 57% of the biogenic carbon sink. Despite the importance of wood products, their production has remained largely limited to undomesticated forest trees with often sub-optimal wood properties that hamper production efficiency. Here, we show that strategic multiplex CRISPR-based genome editing of monolignol biosynthesis genes improves wood properties beyond natural variations or the editing of single genes. By assessing every possible combination of multigenic-editing strategies for 21 lignin biosynthesis genes, we deduced unique genome-editing strategies targeting the concurrent alteration of up to 6 genes. CRISPR-editing increased the wood carbohydrate-to-lignin ratio up to 228% of wildtype, leading to more efficient bioprocessing. The edited wood alleviates a major fiber-production bottleneck and could bring unprecedented operational efficiencies, bioeconomic opportunities, and environmental benefits.
日期：2024年5月29日(星期三)
時間：10:20-12:10 AM
地點：臺大森林系館 林一教室